Last edited by Kazrashakar
Friday, July 24, 2020 | History

4 edition of Pharmacology of lipid transport and atherosclerotic processes. found in the catalog.

Pharmacology of lipid transport and atherosclerotic processes.

  • 325 Want to read
  • 40 Currently reading

Published by Pergamon Press in Oxford, New York .
Written in English

    Subjects:
  • Arteriosclerosis.,
  • Lipids -- Metabolism.,
  • Lipids -- Metabolism -- Disorders.,
  • Lipotropic agents.,
  • Arteriosclerosis -- Metabolism.,
  • Biological transport, Active.,
  • Lipids -- Metabolism lipoproteins -- Blood.

  • Edition Notes

    Includes bibliographies.

    StatementContributors: S. Abraham [and others]
    SeriesInternational encyclopedia of pharmacology and therapeutics,, section 24
    ContributionsAbraham, Samuel, 1923-
    Classifications
    LC ClassificationsRC692 .P36 1975
    The Physical Object
    Paginationix, 595 p.
    Number of Pages595
    ID Numbers
    Open LibraryOL5045938M
    ISBN 10008017762X
    LC Control Number74006188

    Overall, lipid synthesis can branch in 2 ways. Fatty acid synthesis: Fatty acids (FAs), triglycerides (TGs) for fat storage. Cholesterol synthesis: Important for cell membrane structure, steroid synthesis, and bile acid synthesis. Each of these relates to common topics in other systems, such as atherosclerosis, hypercholesterolemia, and. Keywords:Cardiovascular risk, dyslipidemias, lipid lowering therapy, lipoproteins, statins, stroke. Abstract:Dyslipidemia represents one of the major risk factors for atherosclerosis affecting the arteries of large and medium caliber and consequently causing ischemia in the brain, heart, or legs. Coronary artery disease and cerebral stroke.

    Hepatic lipid content, quantification of atherosclerosis, assessment of oxidative stress and inflammation, gene expressions were performed on liver and aorta samples. The data showed that hesperidin ameliorated HFD-induced weight gain, improved insulin . Describe how the liver plays a central role in lipid transport and metabolism and how hepatic VLDL secretion is regulated by the diet and hormones. Indicate the roles of LDL and HDL in promoting and retarding, respectively, the development of atherosclerosis. Indicate the causes of alcoholic and nonalcoholic fatty liver disease (NAFLD).

    The book is clearly written and well illustrated and will give the reader a better understanding of the mechanisms of drug action as well as insight into the development of new drugs. Pharmacology of Intestinal Permeatioo-Edited by T. Z. Csaky. Handbook of Experimental Pharmacology, Vol parts I and II. Part I, pp. THE ENTEROCYTE, CHOLESTEROL HOMEOSTASIS, AND HDL. Cholesterol is essential in all mammalian cells as a structural component of cell membranes and as a precursor of a large variety of molecules critical in biological functions such as bile acids (BAs), steroid hormones, and vitamin D ().Cellular cholesterol requirements are met through de novo synthesis; however, in the presence of .


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Pharmacology of lipid transport and atherosclerotic processes Download PDF EPUB FB2

Pharmacology of Lipid Transport and Atherosclerotic Processes, Volume 1 International encyclopedia of pharmacology and therapeutics, ISSN Pharmacology of Lipid Transport and Atherosclerotic Processes, Samuel Abraham Volume 24 of Urban and Regional Planning Series: Contributor: Samuel Abraham: Edition: illustrated: Publisher.

Additional Physical Format: Online version: Pharmacology of lipid transport and atherosclerotic processes. Oxford, New York, Pergamon Press []. Medicinal Chemistry: Lipid Pharmacology, Volume 2 focuses on the effects of drugs on lipid metabolism.

This book explores the methodology in lipid chemistry by which transport and release mechanisms can be investigated very effectively by the use of drugs.

Organized into 12 chapters, this book starts with an overview of the total lipid fraction Book Edition: 1. Lipid diseases and pharmacology: By far the most common clinical presentation related to altered lipids is hyperlipidemia (actually lipemia), which is an important risk factor in developing atherosclerosis and heart disease.

There are six types of hyperlipidemias (I, IIa, IIb, III, IV, and V), which are differentiated by the type(s) of lipids. This transport, called reverse cholesterol transport (RCT), is a highly regulated Pharmacology of lipid transport and atherosclerotic processes. book that relies on specific interactions between HDL particles and cell membranes [28,31].

It involves multiple steps and components, such as cholesterol efflux from lipid-laden macrophages, HDL-modifying enzymes, and hepatic HDL receptors. This process involves LDL receptor-mediated endocytosis and requires Apo E. The liver may now excrete the cholesterol into bile (either unchanged or as bile acids), incorporate it into membranes, or resecrete it into plasma as lipoprotein cholesterol.

Endogenous Lipid Transport: The VLDL-LDL Cycle (Apo B System). The first edition of this book was published in The content of the 4th edition reflects the enormous advances that have occurred since that time in the field of lipid biochemistry.

This publication is unique in that it represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific.

In contrast, it remains to be determined whether targeting protective lipid factors or inflammatory mediators of atherosclerosis will be clinically beneficial. AB - Introduction: For more than two decades, lowering levels of low-density lipoprotein cholesterol has formed the cornerstone of management of patients with atherosclerotic.

Low-density lipoprotein receptor (LDLR) has long been studied for its role in cholesterol transport and lipid metabolism. The functions of LDLR-related proteins (LRPs), other members in the LDLR superfamily, in regulating signal transduction in a broad range of biological processes.

Atherosclerosis is an arterial disorder that comes from Greek words athera which means porridge and sclereni which means hardening of arteries. It is an inflammatory disorder, in which the lipid plaques along with inflammatory responses accumulate inside the arteries resulting in hardening and narrowing of the arteries and therefore restricting blood flow.

Luk, A.I. Gotlieb, in Pathobiology of Human Disease, Abstract. Atherosclerosis is a chronic inflammatory vascular disease characterized by the formation of an atherosclerotic plaque (atheroma or fibroinflammatory lipid plaque) in the vessel wall of medium- or large-sized elastic or muscular arteries, thereby impairing arterial function.

Lesions develop at sites of endothelial injury. Daniel J. Rader, in Clinical Lipidology, PROMOTING MACROPHAGE CHOLESTEROL EFFLUX THROUGH LIVER X RECEPTOR AGONISM. Promotion of macrophage RCT is considered one of the “holy grails” for the treatment of atherosclerosis.

46 Therapy to promote the first step of this process relevant to atherosclerosis, namely cholesterol efflux from macrophages, is of obvious interest.

Introduction. Atherosclerosis is a chronic and progressive vascular disease, having as ultimate outcome the atheromatous plaque located on the luminal surface of arteries (Weber et al. ).There is increasing evidence indicating that enhancement of reverse cholesterol transport (RCT) is inversely correlated with the development of atherosclerosis.

A new focus on this processhas examined how cholesterol loading of macrophages increased the expression of netrin 1 and semaphorin 3E, which inhibit migration causing retention of macrophages in atherosclerotic lesions,a process that involves lipid-raft microdomains where the semaphorin receptor is located.

High blood cholesterol and high blood triglycerides are causal risk factors for atherosclerotic cardiovascular disease, which remains the leading cause of death in the developed world. Lipid and lipoprotein metabolism—cholesterol, triglycerides, and fat-soluble vitamins are transported with specific proteins in the blood as multimeric complexes called lipoproteins.

Lipid and lipoprotein. A lipoprotein is a biochemical assembly whose primary purpose is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular have a single-layer phospholipid and cholesterol outer shell, with the hydrophilic portions oriented outward toward the surrounding water and lipophilic portions oriented inward toward the lipids molecules.

In biology and biochemistry, a lipid is a macrobiomolecule that is soluble in nonpolar solvents. Non-polar solvents are typically hydrocarbons used to dissolve other naturally occurring hydrocarbon lipid molecules that do not (or do not easily) dissolve in water, including fatty acids, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E, and K), monoglycerides, diglycerides.

Atherosclerosis, perhaps more than any other widespread and life-threatening pathological process of modern times, needs to be studied using experimental models.

Reverse cholesterol transport is a key event in lipid metabolism. Caveolae and caveolin-1 are in the center stage of cholesterol transportation and inflammation in macrophages. Here, we propose that reverse cholesterol transport and inflammation in atherosclerosis can be integrated by caveolae and caveolin Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology.

It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information.

Atherosclerosis ; Brizzi P, Tonolo G, Esposito F, et al. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynecol ; Enquobahrie DA, Williams MA, Butler CL, et al. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia.

Am J Hypertens ; Fanshawe AE, Ibrahim M.Lipid-soluble substances moves across the lipoprotein membrane by a passive transfer process called simple diffusion. It is proportional to the concentration gradient (difference) of the drug across the membrane and the degree of lipid solubility degree of lipid solubility.

Active Transport. A process where a substance is transported. Evidence for a role of phospholipid oxidation products in atherosclerosis.

The role of phospholipid oxidation products (Ox-PL) in atherogenesis was first suggested by the demonstration that pro-atherogenic activities of low-density lipoprotein (LDL) mildly oxidized by iron, myeloperoxidase or lipoxygenase were present in the fraction containing oxidized phospholipids.

1 Subsequently.